English

Physiological Relevance and Therapeutic Value of Micro RNA in Cancer

Post transcriptional gene silencing (PTGS) using RNA interference plays an important role against the regulation of parasitic genes. Intensive research during the last few decades on technologies using various interfering RNA molecule to ablate the genes has contributed to new paradigm in the diagnosis and treatment of cancer. It is a promising strategy to inhibit the expression of pathologically relevant genes. PTGS can be mediated either by short or small nuclear RNA (SnRNA) or by micro RNA (miRNA). Among the gene ablation techniques, SnRNA holds superior to the previously demonstrated treatments using antisense oligonucleotides. Expression of miRNA in cancer and their detection by miRNA microarray especially in breast, ovaries, cervix, colon, lung, liver, brain, esophagus, prostate, pancreas, and thyroid cancers have proposed their role in the diagnosis as well as prognosis of cancer treatment. Recently, emerging research in this field adds worth as well as contribution to the development of miRNA based cancer therapy.

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