English

Metabolite Profiling to Characterize Disease-related Bacteria: GLUCONATE EXCRETION BY PSEUDOMONAS AERUGINOSA MUTANTS AND CLINICAL ISOLATES FROM CYSTIC FIBROSIS PATIENTS*.

This article is from The Journal of Biological Chemistry , volume 288 . Abstract Background: Phenotypic profiling of knockout libraries is a possible functional genomics strategy.Results: Gluconate excretion is a novel phenotype of the Pseudomonas aeruginosa rpoN mutant, which is also weakly associated with antibiotic susceptibility in a clinical strain panel.Conclusion: The rpoN phenotype results from catabolite repression deregulation of 6-phosphogluconate dehydratase.Significance: NMR profiling can uncover novel gene functions with potential clinical relevance.

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