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Pathophysiological events of ARDS

This image is part of a series that was created for an open textbook, Pulmonary Pathophysiology for Pre-Clinical Students . The textbook will be available Summer 2022. Preferred citation: Kindred Grey (2022). "Pathophysiological events of ARDS." CC BY 4.0 . Other contributions to this image: None Alternative text: Initiating insult arrives (via airway or blood) arrow to diffuse alveolar damage arrow to release of TNF, IL-1, IL-6 and IL-8 arrow to neutrophils attracted to the lungs (macrophages/fibroblasts) arrow to neutrophils release toxic mediators (ROS, proteases) arrow to capillary endothelium/alveolar epithelium damage arrow to protein escapes into the interstitial tissue, fluid follows arrow to airspaces fill with fluid, debris, protein and formation of hyaline membrane.

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