English

DTIC AD0840847: SPECIFICITY OF ANTI-RNA ANTIBODIES (SPECIFICITE DES ANTICORPS ANTI-RNA)

The anti-RNA antibodies present in the sera of animals immunized with ribonucleoproteins (ribosomes) have been characterized as gamma-globulins. This character 'gamma-globulinic' is also exhibited by the proteins 'gamma I' precipitated by 'Poly I' from human sera and from the sera of nonimmunized animals. The serum titer of these proteins 'gamma I' increases with the age of the animal (chicken) and even much greater increases are found when animals are immunized with ribosomes. On the other hand, in sera containing antibodies to other antigens, the 'gamma I' titer does not increase, but sometimes even diminishes as immunization is continued. From an anti-ribosomal horse serum, two broad categories of antibodies to RNA, 'a' and 'b', exhibiting physico-chemical and immunological differences have been isolated. These fractions 'a' and 'b' interact with varying intensity with all of the polyribonucleotides and RNA used, but differ in their respective abilities of forming soluble or precipitating complexes with some of them. Their specificity is such that they react uniquely with polyribonucleotides and more specifically with the polyribose phosphate groups.

Sign in with your free account to read, download EPUBs or listen.