English

DTIC AD1007726: Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse

The purpose of this work is to utilize monocyte/macrophage-enabled delivery, a novel therapeutic delivery system that we pioneered, to increase the effectiveness and decrease thetoxicity of the treatment of intracranial metastases from primary breast cancer. Our objective in this proposal is to deliver therapeutics to brain metastases using a nanoshell(NS)-double-stranded DNA (dsDNA)-drug complex loaded within monocytes/macrophages. Once present within the metastasis, we aim to release the drug by transcranial irradiation atnear-infrared (NIR) wavelengths. Our studies have provided fundamental information on a number of aspects of the delivery of therapeutics by NSdsDNA.

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