English

DTIC AD1049270: A National Coordinating Center for Prehospital Trauma Research Funding Transfusion Using Stored Fresh Whole Blood

Resuscitation protocols for trauma patients presenting with significant bleeding utilize administration of components of blood including RBCs, plasma, and platelets. Despite improvements in emergency surgery and critical care, trauma patients with severe bleeding still suffer from high incidence of complications and death compared to patients that require fewer or no transfusions. Recent studies from military centers indicate that transfusion of FWB may be more beneficial than individual blood components in patients with severe hemorrhage. This has not been studied in civilian trauma patients mainly due to the technical difficulties and costs. We propose a feasibility and hospital outcomes study using FWB (storage time of 5 days) for resuscitating trauma patients with significant bleeding. A cohort of adult trauma patients presenting with severe hemorrhage and receiving resuscitation with FWB will be prospectively compared to a control group of patients receiving standard component therapy. The shelf-life of whole blood, cost of treatment, levels of clotting and inflammatory markers in patients blood samples, as well as the incidence of persistent bleeding, development of blood clo

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