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DTIC ADA190156: Acute Inhalation Toxicity of a Saline Suspension of T-2 Mycotoxin in Mice

Acute Inhalation Toxicity of a Saline Suspension of T-2 Mycotoxin and Mice. CREASIA, D.A., NEALLEY, M.L., JONES, L.J., III, YORK, C.G., WANNEMACHER, R,W,, JP., AND BUNNER, D.L.(1986). Toxicol. Appl. Pharmacol. In a previous paper (Creasia et al., 1986), we reported that inhalation of an ethanol/T-2 aerosol was 20 to 40 times more toxic to mice than systematic or dermal administration of T-2. There was concern, however, that the aerosolized ethanol vehicle might alter absorption of inhaled T-2 from the respiratory tract. In order to eliminate this question, we exposed mice to aerosols of T-2 in saline. We found that the LC50 for mice after a 10-min aerosol exposure of T-2 in saline was 0.04 + or - 0.008 mg T-2/liter of air, lower than the LC50 (0.080 + or - 0.02 mg T-2/ liter) for an aerosol of T-2 in ethanol. We also found that, for any comparable total body burden of T-2, mice exposed to T-2 in saline retained a greater percent of T-2 in the respiratory tract than did mice exposed to T-2 in ethanol. This suggests that the respiratory tract may be a target organ for inhaled T-2 mycotoxin. Keywords: Phytotoxins.

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