English

DTIC ADA229531: Occupational Criteria for Chemical Agent VX

The U.S. Army has stockpiles of chemical agents that are or will be undergoing demilitarization; among these is the chemical agent VX. Military and civilian munition personnel involved in the demilitarization of VX will be potentially at risk from accidental exposures. In order to ensure the safety of these workers, the current standards must be reevaluated in light of the most recent toxicological data, using the most appropriate methodology for determining maximum safe exposure limits. In this report, toxicological data for VX are reviewed to determine the most significant toxicological effects for defining minimum and no-effect levels; the basis for the current occupational standard is discussed; and a standard for VX is derived from both human and animal data correlating VX exposure to the inhibition of erythrocyte acetylcholinesterase. Keywords: Chemical agent VX, Occupational criteria, Toxicology.

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