English

DTIC ADB154041: Characterization of Soman Toxicity in Atropine and Oxime (HI-6 and MMB- 4) Treated Rhesus Monkeys

A study was instituted to characterize in rhesus monkeys the toxicity, based on lethality, morbidity, and pathology, of GD when exposure was followed by treatment with atropine and either of two test oximes, HI-6, and MMB-4. The 48 hour LD-50 was determined for untreated monkeys and monkeys treated with atropine/HI-6 and atropine MMB-4. HI-6 was significantly more effective than MMB-4 in treating GD intoxication. The times to death were significantly longer for animals treated with atropine/HI-6. Duration of tremors, convulsions, and prostration were determined to not be significantly related to either GD dose or treatment group.

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