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Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis*.

Nobuyoshi Kosaka Haruhisa Iguchi Keitaro Hagiwara Yusuke Yoshioka Fumitaka Takeshita Takahiro Ochiya

This article is from The Journal of Biological Chemistry , volume 288 . Abstract Background: Contribution of exosomal microRNAs to cancer metastasis remains unknown.Results: Exosomal angiogenic microRNAs secreted by metastatic cancer cells promote the metastasis through the activation of endothelial cells.Conclusion: Horizontal transfer of exosomal miRNAs from cancer cells can dictate the microenviromental niche for the benefit of the cancer cell.Significance: This is the first to connect cancer metastasis to the exosomal microRNA in vivo.

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Ebook · Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis*. · Kosaka, Nobuyoshi, Iguchi, Haruhisa, Hagiwara, Keitaro, Yoshioka, Yusuke, Takeshita, Fumitaka, Ochiya, Takahiro · Internet Archive

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