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A Single Divergent Exon Inhibits Ankyrin-B Association with the Plasma Membrane.

This article is from The Journal of Biological Chemistry , volume 288 . Abstract Background: Ankyrin-B is intracellular, whereas ankyrin-G associates with plasma membranes.Results: An ankyrin-B-specific linker between the ANK repeat domain and the ZU52-UPA module inhibits ankyrin-B binding to membrane protein partners and localization to plasma membranes of epithelial cells and neurons.Conclusion: The linker region contributes to functional differences between ankyrins.Significance: This work explains the distinct behavior of ankyrins regarding plasma membrane localization.

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