English

Small Molecule-facilitated Degradation of ANO1 Protein: A NEW TARGETING APPROACH FOR ANTICANCER THERAPEUTICS.

This article is from The Journal of Biological Chemistry , volume 289 . Abstract Background: The calcium-activated chloride channel ANO1 is highly expressed in cancer.Results: Inhibition of ANO1 activity alone is not sufficient to inhibit cancer cell proliferation, suggesting a novel function of ANO1 protein in cancer.Conclusion: The ANO1 inhibitor CaCCinh-A01 inhibits cancer cell proliferation by facilitating degradation of ANO1.Significance: Our results may provide a new targeting approach for antitumor therapy in ANO1-amplified cancers.

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