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Concordance of the tuberculin skin test and T-SPOT®.TB test results in kidney transplant candidates.

This article is from Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences , volume 19 . Abstract Background:: Detection of latent tuberculosis infection (LTBI) in transplant candidates is very important. The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are standard immunologic tools for LTBI detection. The aim of this study was to compare the TST results and T-SPOT®.TB test (a type of IGRAs) in kidney transplant candidates for the screening of LTBI and follow the patients with positive test for an activation of tuberculosis (TB) after transplantation and using anti-TB prophylaxis. Materials and Methods:: This study was a prospective study and carried out in 44 renal transplant candidates from March 2010 to February 2011 in the teaching hospitals of Isfahan University of Medical Sciences, Iran. TST and T-SPOT®.TB test were performed and their results evaluated. Patients with a positive skin test and/or T-SPOT®.TB test were started on anti-TB prophylaxis and followed after transplantation for an activation of their LTBI for 1 year. Results:: Overall, 8 (18.2%) patients were positive for TST and 6 (13.6%) pa

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