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Hemostatic Profile in Healthy Premature Neonates; Does Birth Weight Affect the Coagulation Profile?

This article is from Journal of Clinical Neonatology , volume 3 . Abstract Context:: There are limited studies assessing the neonatal hemostatic factors in relation to birth weight. Aims:: This study aims to compare the coagulation factors between three groups of neonates with different birth weight for gestational age (GA). Settings and Design:: In a cross-sectional study, 74 healthy premature neonates were involved. Subjects and Methods:: Serum prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin clotting time (TT), and levels of fibrinogen, anti-thrombin III, protein S and protein C were measured. Neonates were classified into three groups according to birth weight, including small, appropriate and large for gestational age (SGA, AGA, and LGA). Statistical Analysis Used:: Statistical analysis was performed using SPSS software. Results:: There was a significant difference in the levels of protein S (P 0.05). Protein S concentration, directly (B = 0.78, P < 0.001), and APTT, inversely (B = −0.29, P = 0.03), associated with birth weight after adjustment for GA and sex. Conclusions:: Despite the decrease in APTT from SGA

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