English

DTIC ADA150100: Chemical Characterization and Toxicologic Evaluation of Airborne Mixtures. Inhalation Toxicology of Diesel Fuel Obscurant Aerosol in Sprague-Dawley Rats. Phase 3. Subchronic Exposures.

Inhalation exposures were performed twice per week, for 13 weeks, to determine whether there was any potential toxicity to rats of comparatively low concentrations of a condensation aerosol from diesel fuel. Animals were divided into 4 groups (24 per sex in each group) and exposed to aerosol concentrations of 0, 0.25, 0.75 and 1.50 mg diesel fuel aerosol/L for 4 hours per day. A fifth group (12 per sex) was used as vivarium controls. Body weight and food consumption were measured weekly for duration of the exposure and also during a two month recovery period. Changes in breathing frequency and the response of animals to a loud sharp sound (startle response) were measured in selected animals prior to the start of the exposures, at various time points during the thirteen week exposure period, and at monthly intervals during the recovery period. Assays were performed on selected animals at the end of the exposure period, and again after the two month recovery period. Endpoints included pulmonary function tests, numbers of alveolar free cells, clinical chemistry, hematology, organ weights and histopathology. No mortalities were recorded during the exposure or recovery periods. Originat

Sign in with your free account to read, download EPUBs or listen.