English

DTIC ADA237516: Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Volume 1

This report presents the results of the serum dioxin analysis of the Air Force Health Study 1987 examination cycle. Its purpose is to determine whether long-term health effects are associated with serum dioxin levels for the participants in the study. For each health effect variable, analyses were performed to evaluate the relationships with initial serum dioxin (extrapolated from a first-order pharmacokinetics model); current serum dioxin and time since tour; and categorized current dioxin levels (providing contrasts of Ranch Hands with specified current dioxin levels versus Comparisons with background levels). Significant associations between serum dioxin and several lipid-related health indices were found in these analyses. Specifically, significant associations with dioxin were found for diabetes, percent body fat, cholesterol. High Density Lipoproteins (HDL), and cholesterol-HDL ratio. Other variables, such as the spirometric indices in the pulmonary assessment and benign systemic neoplasms (over 70% were lipomas) in the malignancy assessment, showed significant associations that may be related to the body fat results. Partial contents: Dioxin assay; Relationship between the e

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